In 1557, a pandemic strain of influenza emerged in Asia, then spread to Africa, Europe, and eventually the Americas. This flu was highly infectious and presented with intense, occasionally lethal symptoms. Medical historians like Thomas Short, Lazare Rivière and Charles Creighton gathered descriptions of catarrhal fevers recognized as influenza by modern physicians[1][2][3][4][5] attacking populations with the greatest intensity between 1557 and 1559.[6][7] The 1557 flu saw governments, for possibly the first time, inviting physicians to instill bureaucratic organization into epidemic responses.[4] It is also the first pandemic where influenza is pathologically linked to miscarriages,[8] given its first English names,[2][9] and is reliably recorded as having spread globally. Influenza caused higher burial rates, near-universal infection, and economic turmoil as it returned in repeated waves.
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^Eichel, Otto R. (December 1922). "The Long-Time Cycles of Pandemic Influenza". Journal of the American Statistical Association. 18 (140). Taylor & Francis: 451. doi:10.1080/01621459.1922.10502488. JSTOR2276917.
^ abAlibrandi, Rosemarie (2018). "When early modern Europe caught the flu. A scientific account of pandemic influenza in sixteenth century Sicily". Medicina Historica. 2: 19–26.
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^Institute of Medicine (US) Forum on Microbial Threats; Knobler, Stacey L.; Mack, Alison; Mahmoud, Adel; Lemon, Stanley M. (2005). The Story of Influenza. National Academies Press (US). Archived from the original on 2020-12-23. Retrieved 2020-05-16.
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