The 1922 Grand Prix season had several notable events during the year. The AIACR governing body brought in a 2-litre formula for Grand Prix. French companies brought out straight-8 engines for their cars but it was FIAT's 6-cylinder engine that took the trophies. Veteran Felice Nazzaro won the French Grand Prix, held near Strasbourg. It was a tainted victory though, as Nazzaro's nephew was killed when his FIAT's suspension broke in the latter stages of the race. An almost identical accident also happened to team-mate Pietro Bordino, though he was only slightly injured. Pierre de Vizcaya's Bugatti finished second, nearly an hour behind.
The first Italian Grand Prix had been held in 1921 on public roads near Brescia. Following the example set elsewhere, land was leased in the Monza Park north-east of Milan to construct a closed circuit. The combined road course and racing oval was exactly 10 km in total length and built in just 101 days. After FIAT's dominance in France, most teams stayed away for the first Italian Grand Prix held at the Autodromo Nazionale Monza and only eight cars started. This time the junior driver beat the master, with Bordino leading home Nazzaro by two laps. De Vizcaya was the only other finisher, a further two laps back.
At the start of the season, Italian privateer Conte Giulio Masetti won the Targa Florio for a consecutive year, running a 1914 GP Mercedes. A number of manufacturers had sent works teams to this event, but Masetti's local knowledge and driving skill gave him a narrow victory over Jules Goux's Ballot.
Jimmy Murphy bought the Duesenberg he had won the French Grand Prix in the previous year and got it fitted with a Miller engine for the Indianapolis 500. There were also significant works teams from Duesenberg and Frontenac. Jules Goux also bought a pair of Ballots from France. Murphy set the fastest practice time and had a dominating drive to win by three minutes from Harry Hartz (Duesenberg) and Eddie Hearn (Ballot). He became the first driver to win the race from pole position. Duesenberg took eight of the top ten places.