| Third edition of the Challenge Desgrange-Colombo | |
| Details | |
|---|---|
| Dates | 18 March – 22 October |
| Location | Europe |
| Races | 10 |
| Champions | |
| Individual champion |  Ferdinand Kübler (SUI) (Fréjus) |
| Nations' champion |  Italy |
The 1950 Challenge Desgrange-Colombo was the third edition of the Challenge Desgrange-Colombo. It included ten races: all the races form the 1949 edition were retained with no additions.