| Fourth edition of the Challenge Desgrange-Colombo | |
| Details | |
|---|---|
| Dates | 19 March – 21 October |
| Location | Europe |
| Races | 11 |
| Champions | |
| Individual champion |  Louison Bobet (FRA) (Stella–Dunlop) |
| Nations' champion | France |
The 1951 Challenge Desgrange-Colombo was the fourth edition of the Challenge Desgrange-Colombo. It included eleven races: all the races form the 1950 edition were retained with the addition of Liège–Bastogne–Liège. Paris–Tours moved from a spring slot to an autumn slot. Louison Bobet won the competition by a single point to 1950 champion Ferdinand Kübler. France won their first nations championship.