| Fifth edition of the Challenge Desgrange-Colombo | |
| Details | |
|---|---|
| Dates | 19 March – 26 October |
| Location | Europe |
| Races | 11 |
| Champions | |
| Individual champion |  Ferdinand Kübler (SUI) (Frejus) |
| Nations' champion |  Italy |
The 1952 Challenge Desgrange-Colombo was the fifth edition of the Challenge Desgrange-Colombo. It included eleven races: all the races form the 1951 edition were retained with no additions. Ferdinand Kübler won his second edition, having previously won in 1950. Italy won the nations championship.