| Sixth edition of the Challenge Desgrange-Colombo | |
| Details | |
|---|---|
| Dates | 18 March – 25 October |
| Location | Europe |
| Races | 11 |
| Champions | |
| Individual champion |  Loretto Petrucci (ITA) (Bianchi–Pirelli) |
| Nations' champion | Italy |
The 1953 Challenge Desgrange-Colombo was the sixth edition of the Challenge Desgrange-Colombo. It included eleven races: all the races form the 1952 edition were retained with no additions. Loretto Petrucci won the individual championship while Italy retained the nations championship.