| Tournament details | |
|---|---|
| Dates | January 31 – April 15 |
| Teams | 10 (from 9 confederations) |
| Final positions | |
| Champions |  Independiente (2nd title) |
| Runners-up |  Peñarol |
| Tournament statistics | |
| Matches played | 26 |
| Goals scored | 83 (3.19 per match) |
| Top scorer(s) |  Pelé (8 goals) |
← 1964 1966 → | |
The 1965 Copa Libertadores de América was the sixth edition of South America's premier club football tournament. Colombia did not send a representative due to the disagreements between CONMEBOL and the Colombian football federation. This became the last edition of the tournament in which only the national champions of each association could participate.
After the victorious campaign the previous year, Independiente would go on to successfully defend the title after beating another Uruguayan team, this time Peñarol. Independiente began a legacy that saw it become a world class football team and paved the way for future conquests.