| Tournament details | |
|---|---|
| Dates | June 27 – November 28 |
| Teams | 21 (from 10 associations) |
| Final positions | |
| Champions |  Boca Juniors (2nd title) |
| Runners-up |  Deportivo Cali |
| Tournament statistics | |
| Matches played | 75 |
| Goals scored | 179 (2.39 per match) |
The 1978 edition of Copa Libertadores was won by Boca Juniors, of Argentina for the second straight year, after defeating Deportivo Cali of Colombia in the final. The defending champions won the two-leg final 0–4 on aggregate, with all four goals coming in the second-leg match after the first leg ended in a goalless draw.