2-Fluoromethamphetamine

Not to be confused with 2-Fluoroamphetamine.

2-Fluoromethamphetamine (2-FMA) is a stimulant drug of the amphetamine family which has been used as a designer drug.[1][2][3] 2-FMA is commonly compared to lisdexamfetamine (Vyvanse), and dextroamphetamine due to its efficacy as a study or productivity aid.[citation needed] 2-FMA is purported to produce somewhat less euphoria than comparable amphetamines, likely due to its main mechanism of action consisting of norepinephrine reuptake inhibition.[4]

2-Fluoromethamphetamine
Ball-and-stick model of the 2-fluoromethamphetamine molecule
Clinical data
Routes of
administration		By mouth
Legal status
Legal status
  • CA: Schedule I[5]
  • DE: Anlage I (Authorized scientific use only)
  • UK: Class A
  • US: Unscheduled
Identifiers
  • (RS)-1-(2-Fluorophenyl)-N-methylpropan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H14FN
Molar mass167.227 g·mol−1
3D model (JSmol)
  • CC(CC1=CC=CC=C1F)NC
  • InChI=1S/C10H14FN/c1-8(12-2)7-9-5-3-4-6-10(9)11/h3-6,8,12H,7H2,1-2H3 checkY
  • Key:XNWIKJYFOIDUGD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)
  1. ^ Cite error: The named reference Rösner was invoked but never defined (see the help page).
  2. ^ Camilleri A, Johnston MR, Brennan M, Davis S, Caldicott DG (April 2010). "Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone". Forensic Science International. 197 (1–3): 59–66. doi:10.1016/j.forsciint.2009.12.048. PMID 20074881.
  3. ^ Ishii A, Sato K, Kusakabe K, Kato N, Wada T (February 2023). "Identification and Quantitative Analysis of 2-Fluoromethamphetamine and Its Metabolites in Human Urine". Journal of Analytical Toxicology. 47 (1): 59–65. doi:10.1093/jat/bkac026. PMID 35562170.
  4. ^ Åstrand A, Guerrieri D, Vikingsson S, Kronstrand R, Green H (December 2020). "In vitro characterization of new psychoactive substances at the μ-opioid, CB1, 5HT1A, and 5-HT2A receptors-On-target receptor potency and efficacy, and off-target effects". Forensic Science International. 317: 110553. doi:10.1016/j.forsciint.2020.110553. PMID 33160102. S2CID 226279968.
  5. ^ Cite error: The named reference :1 was invoked but never defined (see the help page).