The 2005 PharmAssist Players' Championship was held March 23–27 at the Mile One Centre in St. John's, Newfoundland and Labrador. It would be the final Championship featuring just a men's event.
The total purse for the event was $150,000 with $50,000 going to the winning team, which would be Kevin Martin's Edmonton rink. He defeated the hometown rink of Brad Gushue, whose team earned $30,000.