The forty-eighth edition of the Caribbean Series (Serie del Caribe) baseball tournament was played in 2006 in the neighboring cities of Maracay and Valencia in Venezuela, making it the first one to be played in two cities. It was held from February 2 through February 7 featuring the champion teams from The Dominican Republic (Licey), Mexico (Mazatlán), Puerto Rico (Carolina) and Venezuela (Caracas). The format consisted of 12 games, each team facing the other teams twice. The games were played at Estadio José Pérez Colmenares (Maracay) and Estadio José Bernardo Pérez (Valencia).