 | |
| Duration | 8 Rounds |
|---|---|
| Highest attendance | 65,187 |
| Broadcast partners |  BBC Sport |
| Winners |  St. Helens |
| Runners-up |  Huddersfield Giants |
| Biggest home win | Leigh East 86-10 Askam |
| Biggest away win | Ovenden 10-50  York City Knights |
| Lance Todd Trophy | Sean Long |
The 2006 Challenge Cup (also known as the Powergen Challenge Cup due to sponsorship from Powergen) was the 105th tournament played for rugby league's Challenge Cup. It features teams from across Europe including England, Scotland, Wales, France and Russia.
The competition started in January 2006 with the preliminary round where the Gloucestershire Warriors from the Rugby League Conference surprised an established Pennine League team in Illingworth. The final was scheduled to be played at the new Wembley Stadium but in March 2006 it became apparent that the stadium would not be ready for the final on 26 August so it was switched to Twickenham.
In the final St. Helens proved too strong for the Huddersfield Giants, winning by 42 points to 12. It was Huddersfield's first final since 1953, when they also faced St Helens.