The 2006 Grand Prix motorcycle racing season was the 58th Fédération Internationale de Motocyclisme (FIM) Road racing World Championship season. The season consisted out of 17 races for the MotoGP class and 16 for the 125cc and 250cc classes, beginning with the Spanish motorcycle Grand Prix on 26 March 2006 and ending with the Valencian Community motorcycle Grand Prix on 29 October.