The fifty-second edition of the Caribbean Series (Serie del Caribe) was played in 2010. It was held from February 2 through February 7 with the champions teams from Dominican Republic (Leones del Escogido), Mexico (Naranjeros de Hermosillo), Puerto Rico (Indios de Mayagüez) and Venezuela (Leones del Caracas). The format consisted of 12 games, in a double round-robin format with each team facing each other twice. The games were played at Estadio Nueva Esparta in Porlamar, Margarita Island, Venezuela.