| 2018 Challenger Ciudad de Guayaquil | |
|---|---|
| Date | 29 October – 3 November |
| Edition | 14th |
| Surface | Clay |
| Location | Guayaquil, Ecuador |
| Champions | |
| Singles | |
 Guido Andreozzi | |
| Doubles | |
Guillermo Durán /  Roberto Quiroz | |
The 2018 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Guayaquil, Ecuador between October 29 and November 3, 2018.