| 2019 Buffalo Bills season | |
|---|---|
 | |
| Owner | Terry and Kim Pegula |
| General manager | Brandon Beane |
| Head coach | Sean McDermott |
| Home field | New Era Field |
| Results | |
| Record | 10–6 |
| Division place | 2nd AFC East |
| Playoff finish | Lost Wild Card Playoffs (at Texans) 19–22 (OT) |
| Pro Bowlers | |
| AP All-Pros | CB Tre'Davious White (1st team) |
| Uniform | |
 | |
The 2019 season was the Buffalo Bills' 60th overall, 50th in the National Football League (NFL), fifth full under the ownership of Terry and Kim Pegula and third under the head coach/general manager tandem of Sean McDermott and Brandon Beane.
During the offseason, Buffalo acquired several players who would make major contributions on offense. The Bills improved on their 6–10 record from the previous season with a 37–20 win over Miami Dolphins in Week 11, then clinched their second winning season in three years with a 26–15 win over the Dallas Cowboys on Thanksgiving Day. Despite losing 24–17 to the Baltimore Ravens in Week 14, the Bills' 9–4 record marked the first time since 1996 (during the Marv Levy/Jim Kelly era) that the team won at least nine of their first 13 games and matching their highest full-season win total (2004, 2014 and 2017) in the 21st century with four games remaining. With a 17–10 win over the Pittsburgh Steelers in Week 15, not only did the Bills clinch their second playoff berth in three years, but they reached 10 wins for the first time since winning 11 in 1999, which was also the last time the team made the playoffs until 2017.
The Bills defense finished an impressive season with just 259 points allowed, second in the league behind only the New England Patriots. The defense allowed more than 20 points just five times all season, and more than 30 points only once (in Week 8 against the Philadelphia Eagles). Overall, the Bills had the lowest-scoring games in the league with just 573 total points scored and allowed.
The #5 seed Bills attempted to win their first playoff game since 1995 in the wild-card round, but were defeated by the #4 seed Houston Texans 22–19 in overtime after giving up a 16–0 lead. The loss extended their playoff win drought to 25 years.
As of the 2023 season, this is the most recent season the Bills did not advance to the Divisional Round of the playoffs.