| 2019 Challenger Ciudad de Guayaquil | |
|---|---|
| Date | 28 October – 3 November |
| Edition | 15th |
| Surface | Clay |
| Location | Guayaquil, Ecuador |
| Champions | |
| Singles | |
 Thiago Seyboth Wild | |
| Doubles | |
 Ariel Behar /  Gonzalo Escobar | |
The 2019 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the fifteenth edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Guayaquil, Ecuador between October 28 and November 3, 2019.