| 2021 Cary Challenger II | |
|---|---|
| Date | 13–19 September |
| Edition | 8th |
| Surface | Hard |
| Location | Cary, North Carolina, United States |
| Champions | |
| Singles | |
 Mitchell Krueger | |
| Doubles | |
| William Blumberg / Max Schnur | |
The 2021 Cary Challenger II was a professional tennis tournament being played on hard courts. It was the 8th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Cary, North Carolina, United States between 13 and 19 September 2021.