| Duration | 6 rounds |
|---|---|
| Number of teams | 28 |
| Broadcast partners | |
| Winners |  St Helens |
| Runners-up |  Castleford Tigers |
| Biggest home win |  Salford Red Devils 68–4  Widnes Vikings (10 April 2021) |
| Biggest away win |  West Wales Raiders 4–58 Widnes Vikings (21 March 2021) |
| Lance Todd Trophy | Niall Evalds |
| Top try-scorer(s) | 7, Regan Grace ( St Helens) |
The 2021 Challenge Cup, known for sponsorship reasons as the 2021 Betfred Challenge Cup, was the 120th edition of the Challenge Cup, the main rugby league knockout tournament in British rugby league run by the Rugby Football League (RFL). This year's competition will be contested between only the professional clubs.
The competition was won by St Helens who beat Castleford 26–12 at Wembley Stadium on 17 July 2021.
Leeds Rhinos were the defending champions, after defeating Salford Red Devils 17–16 in the 2020 final. However, they were eliminated in round 3, after losing 18–24 to St Helens.