| Copa BetPlay Dimayor 2021 | |
|---|---|
| Tournament details | |
| Country | Colombia |
| Dates | 10 March – 24 November 2021 |
| Teams | 35 |
| Final positions | |
| Champions | Atlético Nacional (5th title) |
| Runner-up | Deportivo Pereira |
| Copa Libertadores | Atlético Nacional |
| Tournament statistics | |
| Matches played | 68 |
| Goals scored | 153 (2.25 per match) |
The 2021 Copa Colombia, officially the Copa BetPlay Dimayor 2021 for sponsorship reasons, was the 19th edition of the Copa Colombia, the national cup competition for clubs of DIMAYOR. The tournament was contested by 35 teams and began on 10 March 2021. It ended on 24 November 2021, with Atlético Nacional winning their fifth title in the competition after defeating Deportivo Pereira in the double-legged final series by a 5–1 aggregate score. As champions, Atlético Nacional qualified for the 2022 Copa Libertadores.
Independiente Medellín were the defending champions, having won the competition in its two most recent editions. They were eliminated by Deportivo Cali in the round of 16.