The 2021 Giro di Sicilia (known as Il Giro di Sicilia EOLO for sponsorship reasons[1]) was the 25th edition of the Giro di Siciliaroad cyclingstage race and the second edition since its revival in 2019.[2] The race was originally scheduled for April but had been postponed due to COVID-19 pandemic restrictions, which had also caused the cancellation of the 2020 edition.[1][3]