| 2021 NCAA Division I softball season | |
|---|---|
 | |
| Duration | February 2021 – June 2021 |
| Preseason No. 1 | UCLA (Unanimous) |
| Defending Champions | UCLA |
| TV partner/s | ESPN |
| NCAA Tournament | |
| Duration | May 20 – June 10, 2021 |
| Most conference bids | SEC, 12 teams |
| Women's College World Series | |
| Duration | June 3–10, 2021 |
| Champions | Oklahoma (5th title) |
| Runners-up | Florida State (14th WCWS Appearance) |
| Winning Coach | Patty Gasso (5th title) |
| WCWS MOP | Giselle Juarez (Oklahoma) |
| Seasons | |
The following human polls made up the 2021 NCAA Division I women's softball rankings. The NFCA/USA Today Poll was voted on by a panel of 32 Division I softball coaches. The NFCA/USA Today poll, the Softball America poll, the ESPN.com/USA Softball Collegiate rankings, and D1Softball ranked the top 25 teams nationally.