| 2021 NCAA Division I softball season | |
|---|---|
 | |
| Duration | February 11 – June 10, 2021 |
| Number of teams | 286 |
| Preseason No. 1 | UCLA |
| Defending Champions | UCLA |
| TV partner/s | ESPN & ESPN+ |
| NCAA Tournament | |
| Duration | May 21 – June 10, 2021 |
| Most conference bids | SEC (12) |
| Women's College World Series | |
| Duration | June 3–10, 2021 |
| Champions | Oklahoma (5th title) |
| Runners-up | Florida State (11th WCWS Appearance) |
| Winning Coach | Patty Gasso (5th title) |
| WCWS MOP | Giselle Juarez (Oklahoma) |
| Seasons | |
The 2021 NCAA Division I Softball season, play of college softball in the United States organized by the National Collegiate Athletic Association (NCAA) at the Division I level, began in February 2021. The season progressed through the regular season, many conference tournaments and championship series, and concluded with the 2021 NCAA Division I softball tournament and 2021 Women's College World Series. The Women's College World Series, consisted of the eight remaining teams in the NCAA Tournament was held in Oklahoma City at USA Softball Hall of Fame Stadium, and ended on June 10, 2021.