| 2021 Nur-Sultan Challenger II | |
|---|---|
| Date | 1–8 March |
| Edition | 4th |
| Surface | Hard (indoor) |
| Location | Nur-Sultan, Kazakhstan |
| Champions | |
| Singles | |
 Tomáš Macháč | |
| Doubles | |
 Nathaniel Lammons / Jackson Withrow | |
The 2021 Nur-Sultan Challenger II was a professional tennis tournament played on indoor hard courts. It was the fourth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Nur-Sultan, Kazakhstan between 1 and 7 March 2021.