| 2021 WTA Lyon Open | |
|---|---|
| Date | 1 – 7 March |
| Edition | 2nd |
| Category | WTA 250 |
| Draw | 32S / 16D |
| Prize money | $235,238 |
| Surface | Hard - Indoors |
| Location | Lyon, France |
| Venue | Halle Tony Garnier |
| Champions | |
| Singles | |
 Clara Tauson | |
| Doubles | |
 Viktória Kužmová /  Arantxa Rus | |
The 2021 WTA Lyon Open (also known as the Open 6ème Sens — Métropole de Lyon for sponsorship reasons) is a women's tennis tournament played on indoor hard courts. It is the second edition of the Lyon Open (WTA) and an International tournament on the 2021 WTA Tour. It will take place at the Halle Tony Garnier in Lyon, France, from 1 to 7 March 2021.