| Administrator(s) | England and Wales Cricket Board |
|---|---|
| Cricket format | Twenty20 |
| Tournament format(s) | League system |
| Champions | No overall winner |
| Participants | 36 |
| Matches | 144 |
| Most runs | Imogen Sidhu (293) |
| Most wickets | Finty Trussler (16) |
The 2021 Women's Twenty20 Cup, known for sponsorship reasons as the 2021 Vitality Women's County T20, was the 12th cricket Women's Twenty20 Cup tournament, taking place in April and May, with 36 teams taking part: 34 county teams plus Scotland and Wales. There was no overall winner, with Hertfordshire, Nottinghamshire, Lancashire, Kent, Gloucestershire and Somerset winning their respective regions.
The 2020 tournament was cancelled due to the COVID-19 pandemic and, following a restructuring of women's cricket in England that saw the ending of the Women's County Championship, the Twenty20 Cup was the only nationwide tournament featuring county sides in 2021. The tournament will be followed by competitions involving regional teams, in 50-over and Twenty20 formats, as well as The Hundred.