| 2022 AON Open Challenger | |
|---|---|
| Date | 19–25 September |
| Edition | 18th |
| Surface | Clay |
| Location | Genoa, Italy |
| Champions | |
| Singles | |
 Thiago Monteiro | |
| Doubles | |
 Dustin Brown /  Andrea Vavassori | |
The 2022 AON Open Challenger was a professional tennis tournament played on clay courts. It was the eighteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Genoa, Italy between 19 and 25 September 2022.