| 2022 Challenger Ciudad de Guayaquil | |
|---|---|
| Date | 31 October – 6 November |
| Edition | 18th |
| Surface | Clay |
| Location | Guayaquil, Ecuador |
| Champions | |
| Singles | |
 Daniel Altmaier | |
| Doubles | |
 Guido Andreozzi / Guillermo Durán | |
The 2022 Challenger Ciudad de Guayaquil was a professional tennis tournament played on clay courts. It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Guayaquil, Ecuador between 31 October and 6 November 2022.