Names | |
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IUPAC name
3′-O-Phosphono-5′-adenylyl hydrogen sulfate
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Systematic IUPAC name
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl hydrogen (sulfooxy)phosphonate | |
Other names
PAPS
3′-Phosphoadenylyl sulfate Phosphoadenosine phosphosulfate 3′-Phospho-5′-adenylyl sulfate | |
Identifiers | |
3D model (JSmol)
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Abbreviations | PAPS |
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.222.927 |
EC Number |
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KEGG | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C10H15N5O13P2S | |
Molar mass | 507.266 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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3′-Phosphoadenosine-5′-phosphosulfate (PAPS) is a derivative of adenosine monophosphate (AMP) that is phosphorylated at the 3′ position and has a sulfate group attached to the 5′ phosphate. It is the most common coenzyme in sulfotransferase reactions and hence part of sulfation pathways.[1] It is endogenously synthesized by organisms via the phosphorylation of adenosine 5′-phosphosulfate (APS), an intermediary metabolite.[2] In humans such reaction is performed by bifunctional 3′-phosphoadenosine 5′-phosphosulfate synthases (PAPSS1 and PAPSS2) using ATP as the phosphate donor.[3][4]