5-HT1A receptor

HTR1A
Identifiers
AliasesHTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled, 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD, 5-hydroxytryptamine receptor 1A
External IDsOMIM: 109760; MGI: 96273; HomoloGene: 20148; GeneCards: HTR1A; OMA:HTR1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000524

NM_008308

RefSeq (protein)

NP_000515

NP_032334

Location (UCSC)Chr 5: 63.96 – 63.96 MbChr 13: 105.58 – 105.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The serotonin 1A receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A is expressed in the brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization and reduction of firing rate of the postsynaptic neuron. In humans, the serotonin 1A receptor is encoded by the HTR1A gene.[5][6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178394Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021721Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (November 1989). "Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia". Genomics. 5 (4): 940–4. doi:10.1016/0888-7543(89)90138-9. PMC 3154173. PMID 2591972.
  6. ^ "Entrez Gene: HTR1A 5-hydroxytryptamine (serotonin) receptor 1A".