5-HT1E receptor

HTR1E
Identifiers
Aliases	HTR1E, 5-HT1E, 5-HT1E receptor, 5-hydroxytryptamine receptor 1E
External IDs	OMIM: 182132; HomoloGene: 55491; GeneCards: HTR1E; OMA:HTR1E - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,016,679 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; prefrontal cortex; ; Brodmann area 9; ; Brodmann area 46; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; superior frontal gyrus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; serotonin binding; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; dendrite;
Biological process	G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; signal transduction; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3354
	n/a
	ENSG00000168830
	n/a
	P28566
	n/a
	NM_000865
	n/a
	NP_000856
	n/a
	Wikidata
View/Edit Human

5-hydroxytryptamine (serotonin) 1e receptor (5-HT_1e) is a highly expressed human G-protein coupled receptor^[3] that belongs to the 5-HT1e receptor family (G_i-coupled serotonin receptor).^[4]^[5] The human gene is denoted as HTR1E.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168830 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leonhardt S, Herrick-Davis K, Titeler M (Aug 1989). "Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein". Journal of Neurochemistry. 53 (2): 465–71. doi:10.1111/j.1471-4159.1989.tb07357.x. PMID 2664084. S2CID 43594695.
^ McAllister G, Charlesworth A, Snodin C, Beer MS, Noble AJ, Middlemiss DN, Iversen LL, Whiting P (Jun 1992). "Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype". Proceedings of the National Academy of Sciences of the United States of America. 89 (12): 5517–21. Bibcode:1992PNAS...89.5517M. doi:10.1073/pnas.89.12.5517. PMC 49323. PMID 1608964.
^ Levy FO, Holtgreve-Grez H, Taskén K, Solberg R, Ried T, Gudermann T (Aug 1994). "Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15". Genomics. 22 (3): 637–40. doi:10.1006/geno.1994.1439. PMID 8001977.
^ "Entrez Gene: HTR1E 5-hydroxytryptamine (serotonin) receptor 1E".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168830 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2664084-3] Leonhardt S, Herrick-Davis K, Titeler M (Aug 1989). "Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein". Journal of Neurochemistry. 53 (2): 465–71. doi:10.1111/j.1471-4159.1989.tb07357.x. PMID 2664084. S2CID 43594695.

[pmid1608964-4] McAllister G, Charlesworth A, Snodin C, Beer MS, Noble AJ, Middlemiss DN, Iversen LL, Whiting P (Jun 1992). "Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype". Proceedings of the National Academy of Sciences of the United States of America. 89 (12): 5517–21. Bibcode:1992PNAS...89.5517M. doi:10.1073/pnas.89.12.5517. PMC 49323. PMID 1608964.

[pmid8001977-5] Levy FO, Holtgreve-Grez H, Taskén K, Solberg R, Ried T, Gudermann T (Aug 1994). "Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15". Genomics. 22 (3): 637–40. doi:10.1006/geno.1994.1439. PMID 8001977.

[entrez-6] "Entrez Gene: HTR1E 5-hydroxytryptamine (serotonin) receptor 1E".

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