5-HT2B receptor

HTR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NC3, 4IB4
Identifiers
Aliases	HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
External IDs	OMIM: 601122; MGI: 109323; HomoloGene: 55492; GeneCards: HTR2B; OMA:HTR2B - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 231,108,230 bp[1] End 231,125,042 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 86,026,748 bp[2] End 86,039,692 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua tail of epididymis stromal cell of endometrium caput epididymis corpus epididymis left adrenal gland left adrenal cortex right adrenal cortex smooth muscle tissue testicle Top expressed in decidua morula Neural groove neural fold embryo tail of embryo genital tubercle calvaria right lung lobe right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity GTPase activator activity signal transducer activity G protein-coupled serotonin receptor activity G-protein alpha-subunit binding serotonin binding neurotransmitter receptor activity Cellular component cytoplasm integral component of membrane membrane plasma membrane synapse cell junction neuron projection integral component of plasma membrane nucleoplasm dendrite Biological process intestine smooth muscle contraction smooth muscle contraction G protein-coupled receptor internalization release of sequestered calcium ion into cytosol regulation of behavior positive regulation of endothelial cell proliferation positive regulation of MAP kinase activity phosphorylation positive regulation of cytokine production vasoconstriction ERK1 and ERK2 cascade positive regulation of phosphatidylinositol biosynthetic process cardiac muscle hypertrophy heart morphogenesis cellular calcium ion homeostasis neural crest cell differentiation negative regulation of apoptotic process negative regulation of cell death activation of phospholipase C activity protein kinase C signaling cGMP biosynthetic process cellular response to temperature stimulus positive regulation of GTPase activity heart development positive regulation of nitric-oxide synthase activity protein kinase C-activating G protein-coupled receptor signaling pathway embryonic morphogenesis serotonin receptor signaling pathway neural crest cell migration positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of I-kappaB kinase/NF-kappaB signaling phosphatidylinositol 3-kinase signaling negative regulation of autophagy positive regulation of cell division calcium-mediated signaling signal transduction phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway animal behaviour cGMP-mediated signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3357 15559 Ensembl ENSG00000135914 ENSMUSG00000026228 UniProt P41595 Q02152 RefSeq (mRNA) NM_000867 NM_001320758 NM_008311 RefSeq (protein) NP_000858 NP_001307687 NP_032337 Location (UCSC) Chr 2: 231.11 – 231.13 Mb Chr 1: 86.03 – 86.04 Mb PubMed search [3] [4]
Wikidata
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5-Hydroxytryptamine receptor 2B (5-HT_2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.^[5][6] 5-HT_2B is a member of the 5-HT₂ receptor family that binds the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT₂ receptors, the 5-HT_2B receptor is G_q/G₁₁-protein coupled, leading to downstream activation of phospholipase C.