5-HT2C receptor

HTR2C
Identifiers
Aliases	HTR2C, 5-HT2C, 5-5HTR1C, 5-HT1C, 5-HT2C receptor, 5-hydroxytryptamine receptor 2C
External IDs	OMIM: 312861; MGI: 96281; HomoloGene: 20242; GeneCards: HTR2C; OMA:HTR2C - orthologs
Gene location (Mouse) Chr. X chromosome (mouse)[1] Band X F2|X 68.46 cM Start 145,745,509 bp[1] End 145,980,273 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus superior vestibular nucleus nucleus accumbens caudate nucleus middle frontal gyrus hypothalamus putamen Region I of hippocampus proper endothelial cell entorhinal cortex Top expressed in Epithelium of choroid plexus medial dorsal nucleus lateral septal nucleus nucleus accumbens anterior amygdaloid area lateral hypothalamus dorsal tegmental nucleus dorsomedial hypothalamic nucleus medial vestibular nucleus olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding G protein-coupled receptor activity signal transducer activity G protein-coupled serotonin receptor activity Gq/11-coupled serotonin receptor activity serotonin binding neurotransmitter receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure dendrite Biological process release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway phospholipase C-activating serotonin receptor signaling pathway locomotory behavior positive regulation of phosphatidylinositol biosynthetic process cellular calcium ion homeostasis behavioral fear response regulation of nervous system process cGMP biosynthetic process phospholipase C-activating G protein-coupled receptor signaling pathway serotonin receptor signaling pathway feeding behavior positive regulation of ERK1 and ERK2 cascade regulation of corticotropin-releasing hormone secretion regulation of appetite positive regulation of fat cell differentiation signal transduction chemical synaptic transmission G protein-coupled receptor signaling pathway animal behaviour cGMP-mediated signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3358 15560 Ensembl n/a ENSMUSG00000041380 UniProt P28335 P34968 RefSeq (mRNA) NM_001256761 NM_000868 NM_001256760 NM_008312 RefSeq (protein) NP_000859 NP_001243689 NP_001243690 NP_032338 Location (UCSC) n/a Chr X: 145.75 – 145.98 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The 5-HT_2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G_q/G₁₁ and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor,^[4][5] that in humans is located on the X chromosome. As males have one copy of the gene and females have one of the two copies of the gene repressed, polymorphisms at this receptor can affect the two sexes to differing extent.