 | This article may be too technical for most readers to understand. (December 2011) |
| 6S / SsrS RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of 6S | |
| Identifiers | |
| Symbol | 6S |
| Rfam | RF00013 |
| Other data | |
| RNA type | Gene |
| Domain(s) | Bacteria |
| SO | SO:0000376 |
| PDB structures | PDBe |
In the field of molecular biology the 6S RNA is a non-coding RNA that was one of the first to be identified and sequenced.[1] What it does in the bacterial cell was unknown until recently. In the early 2000s scientists found out the function of 6S RNA to be as a regulator of sigma 70-dependent gene transcription. All bacterial RNA polymerases have a subunit called a sigma factor. The sigma factors are important because they control how DNA promoter binding and RNA transcription start sites. Sigma 70 was the first one to be discovered in Escherichia coli.[2][3]
- ^ Brownlee GG (February 1971). "Sequence of 6S RNA of E. coli". Nature. 229 (5): 147–149. doi:10.1038/229147a0. PMID 4929322. S2CID 27493698.
- ^ Lee JY, Park H, Bak G, Kim KS, Lee Y (September 2013). "Regulation of transcription from two ssrS promoters in 6S RNA biogenesis". Molecules and Cells. 36 (3): 227–234. doi:10.1007/s10059-013-0082-1. PMC 3887979. PMID 23864284.
- ^ Cite error: The named reference
:0was invoked but never defined (see the help page).