7-Hydroxyamoxapine

7-Hydroxyamoxapine
Pharmacokinetic data
Elimination half-life	6.5 hours
Identifiers
	IUPAC name 2-Chloro-11-(piperazin-1-yl)dibenzo [b,f][1,4]oxazepin-7-ol;
CAS Number	37081-76-8;
PubChem CID	162242;
ChemSpider	142472;
UNII	9Z11F654NR;
ChEBI	CHEBI:143288;
CompTox Dashboard (EPA)	DTXSID00190576 ;
Chemical and physical data
Formula	C17H16ClN3O2
Molar mass	329.78 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CCN1)C2=NC3=C(C=C(C=C3)O)OC4=C2C=C(C=C4)Cl;
	InChI InChI=1S/C17H16ClN3O2/c18-11-1-4-15-13(9-11)17(21-7-5-19-6-8-21)20-14-3-2-12(22)10-16(14)23-15/h1-4,9-10,19,22H,5-8H2; Key:MEUGUMOVYNSGEW-UHFFFAOYSA-N;

7-Hydroxyamoxapine is an active metabolite of the antidepressant drug amoxapine (Asendin). It contributes to amoxapine's pharmacology.^[1]^[2] It is a dopamine receptor antagonist and contributes to amoxapine's antipsychotic properties.^[3]^[4]

^ Jue SG, Dawson GW, Brogden RN (July 1982). "Amoxapine: a review of its pharmacology and efficacy in depressed states". Drugs. 24 (1): 1–23. doi:10.2165/00003495-198224010-00001. PMID 7049659. S2CID 7279867.
^ Calvo B, García MJ, Pedraz JL, Mariño EL, Domínguez-Gil A (April 1985). "Pharmacokinetics of amoxapine and its active metabolites". International Journal of Clinical Pharmacology, Therapy, and Toxicology. 23 (4): 180–185. PMID 3997304.
^ Midha KK, Hubbard JW, McKay G, Rawson MJ, Hsia D (September 1999). "The role of metabolites in a bioequivalence study II: amoxapine, 7-hydroxyamoxapine, and 8-hydroxyamoxapine". International Journal of Clinical Pharmacology and Therapeutics. 37 (9): 428–438. PMID 10507241.
^ Cohen BM, Harris PQ, Altesman RI, Cole JO (September 1982). "Amoxapine: neuroleptic as well as antidepressant?". The American Journal of Psychiatry. 139 (9): 1165–1167. doi:10.1176/ajp.139.9.1165. PMID 6126130.