7SK RNA

Reversible association of P-TEFb with the 7SK snRNP. P-TEFb is released from the 7SK snRNP by Brd4 or HIV Tat. HEXIM is ejected and the two proteins are replaced by hrRNPs. The reverse of this process requires other unknown factors.
7SK RNA
Predicted secondary structure and sequence conservation of 7SK
Identifiers
Symbol7SK
RfamRF00100
Other data
RNA typeGene
Domain(s)Eukaryota
SOSO:0000274
PDB structuresPDBe
RN7SK
Identifiers
SymbolRN7SK
NCBI gene125050
Other data
LocusChr. 6 p12.2

In molecular biology 7SK is an abundant small nuclear RNA found in metazoans.[1] It plays a role in regulating transcription by controlling the positive transcription elongation factor P-TEFb.[2] 7SK is found in a small nuclear ribonucleoprotein complex (snRNP) with a number of other proteins that regulate the stability and function of the complex.

  1. ^ Diribarne G, Bensaude O (2009). "7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor". RNA Biology. 6 (2): 122–8. doi:10.4161/rna.6.2.8115. PMID 19246988.
  2. ^ Peterlin BM, Brogie JE, Price DH (2012). "7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription". Wiley Interdisciplinary Reviews. RNA. 3 (1): 92–103. doi:10.1002/wrna.106. PMC 3223291. PMID 21853533.