A549 cell

A549 cells under DIC microscopy, from a 3-4 days old culture, showing an abundance of intercellular connections, including possible cytonemes, filopodia and other epithelial bridges. (These cells have endocytosed 25x73 nm colloidal gold nanorods.)

A549 cells are adenocarcinomic human alveolar basal epithelial cells, and constitute a cell line that was first developed in 1972 by D. J. Giard, et al. through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58-year-old caucasian male.[1] The cells are used as models for the study of lung cancer and the development of drug therapies against it.[2][3]

  1. ^ "A549 Cell Line: Human alveolar adenocarcinoma cell line -General Information". Retrieved 3 January 2012.
  2. ^ Giard, DJ; Aaronson, SA; Todaro, GJ; Arnstein, P; Kersey, JH; Dosik, H; Parks, WP (1973). "In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors". Journal of the National Cancer Institute. 51 (5): 1417–23. doi:10.1093/jnci/51.5.1417. PMID 4357758.
  3. ^ Cite error: The named reference foster was invoked but never defined (see the help page).