AADAC

AADAC
Identifiers
Aliases	AADAC, CES5A1, DAC, arylacetamide deacetylase
External IDs	OMIM: 600338; MGI: 1915008; HomoloGene: 37436; GeneCards: AADAC; OMA:AADAC - orthologs
EC number	3.1.1.3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	151,828,488 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	59,947,581 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lobe of liver; ; duodenum; ; mucosa of ileum; ; body of pancreas; ; gallbladder;
	Top expressed in
	left lobe of liver; ; right kidney; ; proximal tubule; ; duodenum; ; human kidney; ; precursor cell; ; migratory enteric neural crest cell; ; fetal liver hematopoietic progenitor cell; ; gallbladder; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	serine hydrolase activity; carboxylic ester hydrolase activity; catalytic activity; hydrolase activity; lipase activity; deacetylase activity; triglyceride lipase activity;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; metabolism; positive regulation of triglyceride catabolic process; catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	13
	67758
	ENSG00000114771
	ENSMUSG00000027761
	P22760
	Q99PG0
	NM_001086
	NM_023383
	NP_001077
	NP_075872
	Wikidata
View/Edit Human	View/Edit Mouse

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.^[5]^[6]

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114771 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase". J Biol Chem. 269 (34): 21650–6. doi:10.1016/S0021-9258(17)31855-0. PMID 8063807.
^ ^a ^b "Entrez Gene: AADAC arylacetamide deacetylase (esterase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114771 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8063807-5] Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase". J Biol Chem. 269 (34): 21650–6. doi:10.1016/S0021-9258(17)31855-0. PMID 8063807.

[entrez-6] "Entrez Gene: AADAC arylacetamide deacetylase (esterase)".

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