AANAT (gene)

AANAT
Identifiers
Aliases	AANAT, DSPS, SNAT, aralkylamine N-acetyltransferase
External IDs	OMIM: 600950; MGI: 1328365; HomoloGene: 31013; GeneCards: AANAT; OMA:AANAT - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,470,117 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,488,506 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; granulocyte; ; right testis; ; left testis; ; thymus; ; monocyte; ; blood; ; spleen; ; appendix;
	Top expressed in
	visual cortex; ; primary visual cortex; ; hematopoietic cell; ; granulocyte; ; muscle of leg; ; superior frontal gyrus; ; external carotid artery; ; cerebellar cortex; ; visual system; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; 14-3-3 protein binding; arylamine N-acetyltransferase activity; protein binding; acyltransferase activity; aralkylamine N-acetyltransferase activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; cytosol;
Biological process	melatonin biosynthetic process; response to cytokine; response to organic cyclic compound; photoperiodism; response to copper ion; rhythmic process; response to corticosterone; response to zinc ion; indolalkylamine biosynthetic process; response to calcium ion; response to insulin; response to prostaglandin E; circadian rhythm; N-terminal protein amino acid acetylation; response to cAMP; cellular response to cAMP; response to light stimulus; response to peptide;
	Sources:Amigo / QuickGO
Orthologs
	15
	11298
	ENSG00000129673
	ENSMUSG00000020804
	Q16613
	O88816
	NM_001088; NM_001166579
	NM_009591
	NP_001079; NP_001160051
	NP_033721
	Wikidata
View/Edit Human	View/Edit Mouse

AANAT is a gene that encodes an enzyme aralkylamine N-acetyltransferase.^[5] It is the key regulator of day-night cycle (circadian rhythm). It is found in all animals. In humans it is present on chromosome 17, in chimpanzees chromosome 17, in mouse and sheep chromosome 11, in rat chromosome 10, and in chicken chromosome 18.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129673 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020804 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Aralkylamine N-acetyltransferase".
^ "AANAT". NCBI. Retrieved 2 November 2014.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129673 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020804 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Aralkylamine N-acetyltransferase".

[6] "AANAT". NCBI. Retrieved 2 November 2014.

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