ABCC1

ABCC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CBZ, 4C3Z
Identifiers
Aliases	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1, ATP binding cassette subfamily C member 1, DFNA77
External IDs	OMIM: 158343; MGI: 102676; HomoloGene: 133779; GeneCards: ABCC1; OMA:ABCC1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	16,143,257 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	14,293,601 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ascending aorta; ; gastric mucosa; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; Descending thoracic aorta; ; prostate; ; bone marrow cells; ; skeletal muscle tissue; ; spleen;
	Top expressed in
	stroma of bone marrow; ; skin of external ear; ; endothelial cell of lymphatic vessel; ; olfactory epithelium; ; conjunctival fornix; ; ankle; ; ascending aorta; ; retinal pigment epithelium; ; tunica media of zone of aorta; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ATPase-coupled transmembrane transporter activity; nucleotide binding; ATPase activity; hydrolase activity; ATP binding; transporter activity; ATPase-coupled inorganic anion transmembrane transporter activity; ABC-type vitamin B12 transporter activity; ABC-type xenobiotic transporter activity; ABC-type glutathione S-conjugate transporter activity; glutathione transmembrane transporter activity; ATPase-coupled intramembrane lipid transporter activity; sphingolipid floppase activity; transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; membrane; extracellular exosome; integral component of plasma membrane; vacuolar membrane;
Biological process	cobalamin metabolic process; leukotriene metabolic process; transmembrane transport; cobalamin transport; vitamin transmembrane transport; xenobiotic transmembrane transport; glutathione transmembrane transport; xenobiotic transport; transport; phospholipid translocation; cell chemotaxis; sphingolipid translocation;
	Sources:Amigo / QuickGO
Orthologs
	4363
	17250
	ENSG00000278183; ENSG00000103222
	ENSMUSG00000023088
	P33527
	O35379
NM_004996; NM_019862; NM_019898; NM_019899; NM_019900;
	NM_019901; NM_019902
	NM_008576
	NP_004987
	NP_032602
	Wikidata
View/Edit Human	View/Edit Mouse

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.^[5]^[6]

^ ^a ^b ^c ENSG00000103222 GRCh38: Ensembl release 89: ENSG00000278183, ENSG00000103222 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023088 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cole SP, Deeley RG (May 1993). "Multidrug resistance-associated protein: sequence correction". Science. 260 (5110): 879. Bibcode:1993Sci...260..879C. doi:10.1126/science.8098549. PMID 8098549.
^ Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (December 1992). "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line". Science. 258 (5088): 1650–4. Bibcode:1992Sci...258.1650C. doi:10.1126/science.1360704. PMID 1360704.

[refGRCh38Ensembl-1] ENSG00000103222 GRCh38: Ensembl release 89: ENSG00000278183, ENSG00000103222 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023088 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8098549-5] Cole SP, Deeley RG (May 1993). "Multidrug resistance-associated protein: sequence correction". Science. 260 (5110): 879. Bibcode:1993Sci...260..879C. doi:10.1126/science.8098549. PMID 8098549.

[pmid1360704-6] Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG (December 1992). "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line". Science. 258 (5088): 1650–4. Bibcode:1992Sci...258.1650C. doi:10.1126/science.1360704. PMID 1360704.

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