AB toxin

C2-like exotoxin "A" part
crystal structure of the enzymatic component of iota-toxin from clostridium perfringens with nadh
Identifiers
SymbolADPrib_exo_Tox
PfamPF03496
Pfam clanCL0084
InterProIPR003540
SCOP21giq / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
AB7-type toxin, "B" part
crystal structure of the anthrax toxin protective antigen heptameric prepore
Identifiers
SymbolBinary_toxB
PfamPF03495
InterProIPR003896
SCOP21acc / SCOPe / SUPFAM
TCDB1.C.42
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria, though there is a pore-forming AB toxin found in the eggs of a snail.[1] They can be classified as Type III toxins because they interfere with internal cell function.[2] They are named AB toxins due to their components: the "A" component is usually the "active" portion, and the "B" component is usually the "binding" portion.[2][3] The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit.[4] T

  1. ^ Giglio, M.L.; Ituarte, S.; Milesi, V.; Dreon, M.S.; Brola, T.R.; Caramelo, J.; Ip, J.C.H.; Maté, S.; Qiu, J.W.; Otero, L.H.; Heras, H. (August 2020). "Exaptation of two ancient immune proteins into a new dimeric pore-forming toxin in snails". Journal of Structural Biology. 211 (2): 107531. doi:10.1016/j.jsb.2020.107531. hdl:11336/143650. PMID 32446810.
  2. ^ a b "Bacterial Pathogenesis: Bacterial Factors that Damage the Host - Producing Exotoxins - A-B Toxins". Archived from the original on 2010-07-27. Retrieved 2008-12-13.
  3. ^ De Haan L, Hirst TR (2004). "Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review)". Mol. Membr. Biol. 21 (2): 77–92. doi:10.1080/09687680410001663267. PMID 15204437. S2CID 22270979.
  4. ^ Perelle S, Gibert M, Boquet P, Popoff MR (December 1993). "Characterization of Clostridium perfringens iota-toxin genes and expression in Escherichia coli". Infect. Immun. 61 (12): 5147–56. doi:10.1128/IAI.61.12.5147-5156.1993. PMC 281295. PMID 8225592.