ACOT11

ACOT11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FO5
Identifiers
Aliases	ACOT11, BFIT, STARD14, THEA, THEM1, acyl-CoA thioesterase 11
External IDs	OMIM: 606803; MGI: 1913736; HomoloGene: 11977; GeneCards: ACOT11; OMA:ACOT11 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,639,192 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,662,195 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; buccal mucosa cell; ; duodenum; ; jejunal mucosa; ; left ventricle; ; mucosa of ileum; ; renal medulla; ; mucosa of pharynx; ; human kidney;
	Top expressed in
	gastrula; ; deep cerebellar nuclei; ; median eminence; ; medial vestibular nucleus; ; retinal pigment epithelium; ; inferior colliculi; ; Epithelium of choroid plexus; ; dorsal tegmental nucleus; ; superior colliculus; ; pontine nuclei;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; lipid binding; acyl-CoA hydrolase activity; carboxylic ester hydrolase activity; fatty-acyl-CoA binding; palmitoyl-CoA hydrolase activity; thiolester hydrolase activity; long-chain fatty acyl-CoA binding; myristoyl-CoA hydrolase activity;
Cellular component	extracellular exosome; cytoplasm; cytosol; mitochondrion; mitochondrial matrix;
Biological process	intracellular signal transduction; response to temperature stimulus; response to cold; fatty acid metabolic process; acyl-CoA metabolic process; negative regulation of cold-induced thermogenesis; palmitic acid biosynthetic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	26027
	329910
	ENSG00000162390
	ENSMUSG00000034853
	Q8WXI4
	Q8VHQ9
	NM_147161; NM_015547
	NM_025590; NM_001347159
	NP_056362; NP_671517
	NP_001334088; NP_079866
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene.^[5]^[6]^[7]^[8] This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162390 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034853 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adams SH, Chui C, Schilbach SL, Yu XX, Goddard AD, Grimaldi JC, Lee J, Dowd P, Colman S, Lewin DA (Nov 2001). "BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity". The Biochemical Journal. 360 (Pt 1): 135–42. doi:10.1042/0264-6021:3600135. PMC 1222210. PMID 11696000.
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Sep 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". Journal of Lipid Research. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Sep 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB Journal. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
^ ^a ^b "Entrez Gene: ACOT11 acyl-CoA thioesterase 11".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162390 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034853 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11696000-5] Adams SH, Chui C, Schilbach SL, Yu XX, Goddard AD, Grimaldi JC, Lee J, Dowd P, Colman S, Lewin DA (Nov 2001). "BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity". The Biochemical Journal. 360 (Pt 1): 135–42. doi:10.1042/0264-6021:3600135. PMC 1222210. PMID 11696000.

[pmid16103133-6] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Sep 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". Journal of Lipid Research. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Sep 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB Journal. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.

[entrez-8] "Entrez Gene: ACOT11 acyl-CoA thioesterase 11".

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