ACOT7

ACOT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQ2
Identifiers
Aliases	ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDs	OMIM: 602587; MGI: 1917275; HomoloGene: 15780; GeneCards: ACOT7; OMA:ACOT7 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,393,767 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,356,312 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; pars compacta; ; pons; ; endothelial cell; ; anterior cingulate cortex; ; middle temporal gyrus; ; spinal ganglia;
	Top expressed in
	seminiferous tubule; ; anterior horn of spinal cord; ; medial dorsal nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; medulla oblongata; ; nucleus of stria terminalis; ; medial vestibular nucleus; ; perirhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; fatty-acyl-CoA binding; protein homodimerization activity; carboxylic ester hydrolase activity; long-chain fatty acyl-CoA binding; protein binding; hydrolase activity; acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; thiolester hydrolase activity;
Cellular component	cytosol; nucleoplasm; mitochondrion; extracellular exosome; cytoplasm;
Biological process	medium-chain fatty acid biosynthetic process; medium-chain fatty-acyl-CoA catabolic process; long-chain fatty-acyl-CoA catabolic process; coenzyme A biosynthetic process; palmitic acid biosynthetic process; acyl-CoA metabolic process; lipid metabolism; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11332
	70025
	ENSG00000097021
	ENSMUSG00000028937
	O00154
	Q91V12
NM_181866; NM_007274; NM_181862; NM_181863; NM_181864;
	NM_181865
NM_001146057; NM_001146058; NM_133348; NM_001369273; NM_001369274;
	NM_001369275; NM_001369276
	NP_009205; NP_863654; NP_863655; NP_863656
NP_001139529; NP_001139530; NP_579926; NP_001356202; NP_001356203;
	NP_001356204; NP_001356205
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.^[5]^[6]^[7]^[8]

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000097021 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028937 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.
^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
^ ^a ^b "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000097021 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028937 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10578051-5] Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.

[pmid16103133-6] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.

[entrez-8] "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

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