ACSL6

ACSL6
Identifiers
Aliases	ACSL6, ACS2, FACL6, LACS 6, LACS2, LACS5, acyl-CoA synthetase long-chain family member 6, acyl-CoA synthetase long chain family member 6
External IDs	OMIM: 604443; MGI: 894291; HomoloGene: 100939; GeneCards: ACSL6; OMA:ACSL6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,012,243 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,364,756 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; Brodmann area 23; ; primary visual cortex; ; right hemisphere of cerebellum; ; pons; ; seminal vesicula; ; Brodmann area 9; ; endothelial cell; ; right frontal lobe; ; left testis;
	Top expressed in
	olfactory epithelium; ; retinal pigment epithelium; ; deep cerebellar nuclei; ; central gray substance of midbrain; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; anterior horn of spinal cord; ; inferior colliculi; ; pontine nuclei; ; neural layer of retina;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; ligase activity; catalytic activity; enzyme binding; ATP binding; decanoate-CoA ligase activity; long-chain fatty acid-CoA ligase activity;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; plasma membrane; peroxisomal membrane; peroxisome; mitochondrial outer membrane; endoplasmic reticulum; mitochondrion;
Biological process	acyl-CoA metabolic process; lipid metabolism; fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; metabolism; long-chain fatty acid metabolic process; neuroblast proliferation;
	Sources:Amigo / QuickGO
Orthologs
	23305
	216739
	ENSG00000164398
	ENSMUSG00000020333
	Q9UKU0
	Q91WC3
NM_015256; NM_001009185; NM_001205247; NM_001205248; NM_001205250;
	NM_001205251
	NM_001033597; NM_001033598; NM_001033599; NM_144823
NP_001009185; NP_001192176; NP_001192177; NP_001192179; NP_001192180;
	NP_056071
	NP_001028769; NP_001028770; NP_001028771; NP_659072
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.^[5]^[6]^[7] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020333 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: acyl-CoA synthetase long-chain family member 6".
^ ^a ^b Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. doi:10.1042/0264-6021:3440135. PMC 1220623. PMID 10548543.
^ Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. doi:10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E. PMID 10502316.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164398 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020333 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: acyl-CoA synthetase long-chain family member 6".

[pmid10548543-6] Malhotra KT, Malhotra K, Lubin BH, Kuypers FA (November 1999). "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors". Biochem. J. 344 Pt 1 (Pt 1): 135–43. doi:10.1042/0264-6021:3440135. PMC 1220623. PMID 10548543.

[pmid10502316-7] Yagasaki F, Jinnai I, Yoshida S, Yokoyama Y, Matsuda A, Kusumoto S, Kobayashi H, Terasaki H, Ohyashiki K, Asou N, Murohashi I, Bessho M, Hirashima K (November 1999). "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)". Genes Chromosomes Cancer. 26 (3): 192–202. doi:10.1002/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E. PMID 10502316.

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