ADAM12

ADAM12
Identifiers
Aliases	ADAM12, ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA, ADAM metallopeptidase domain 12
External IDs	OMIM: 602714; MGI: 105378; HomoloGene: 74862; GeneCards: ADAM12; OMA:ADAM12 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	126,388,477 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	133,833,875 bp
RNA expression pattern
	Top expressed in
	placenta; ; stromal cell of endometrium; ; buccal mucosa cell; ; tibia; ; decidua; ; mucosa of paranasal sinus; ; cartilage tissue; ; gallbladder; ; testicle; ; tendon of biceps brachii;
	Top expressed in
	gastrula; ; calvaria; ; body of femur; ; mesothelium of peritoneum; ; umbilical cord; ; decidua; ; facial skeleton; ; efferent ductule; ; mandible; ; lesser wing of sphenoid bone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; peptidase activity; metalloendopeptidase activity; protein binding; hydrolase activity; metal ion binding; metallopeptidase activity;
Cellular component	integral component of membrane; extracellular region; membrane; nucleoplasm; plasma membrane;
Biological process	cell adhesion; myoblast fusion; proteolysis; extracellular matrix organization; positive regulation of angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	8038
	11489
	ENSG00000148848
	ENSMUSG00000054555
	O43184
	Q61824
	NM_021641; NM_001288973; NM_001288974; NM_001288975; NM_003474
	NM_007400
	NP_001275902; NP_001275903; NP_001275904; NP_003465; NP_067673
	NP_031426
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 12 (previously Meltrin) is an enzyme that in humans is encoded by the ADAM12 gene.^[5]^[6] ADAM12 has two splice variants: ADAM12-L, the long form, has a transmembrane region and ADAM12-S, a shorter variant, is soluble and lacks the transmembrane and cytoplasmic domains.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148848 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054555 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM (Feb 1998). "A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo". J. Biol. Chem. 273 (1): 157–66. doi:10.1074/jbc.273.1.157. PMID 9417060.
^ Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM (Jun 2008). "Cellular roles of ADAM12 in health and disease". Int. J. Biochem. Cell Biol. 40 (9): 1685–702. doi:10.1016/j.biocel.2008.01.025. PMID 18342566.
^ Yagami-Hiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa-Sehara A (1995). "A metalloprotease-disintegrin participating in myoblast fusion". Nature. 377 (6550): 652–6. Bibcode:1995Natur.377..652Y. doi:10.1038/377652a0. PMID 7566181. S2CID 4348744.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148848 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054555 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417060-5] Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM (Feb 1998). "A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo". J. Biol. Chem. 273 (1): 157–66. doi:10.1074/jbc.273.1.157. PMID 9417060.

[pmid18342566-6] Kveiborg M, Albrechtsen R, Couchman JR, Wewer UM (Jun 2008). "Cellular roles of ADAM12 in health and disease". Int. J. Biochem. Cell Biol. 40 (9): 1685–702. doi:10.1016/j.biocel.2008.01.025. PMID 18342566.

[7] Yagami-Hiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa-Sehara A (1995). "A metalloprotease-disintegrin participating in myoblast fusion". Nature. 377 (6550): 652–6. Bibcode:1995Natur.377..652Y. doi:10.1038/377652a0. PMID 7566181. S2CID 4348744.

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