ADAMTS1

ADAMTS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JIH, 2V4B, 3Q2G, 3Q2H
Identifiers
Aliases	ADAMTS1, C3-C5, METH1, ADAM metallopeptidase with thrombospondin type 1 motif 1
External IDs	OMIM: 605174; MGI: 109249; HomoloGene: 21381; GeneCards: ADAMTS1; OMA:ADAMTS1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	26,845,409 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	85,600,001 bp
RNA expression pattern
	Top expressed in
	right ovary; ; left uterine tube; ; vena cava; ; left ovary; ; pericardium; ; gastric mucosa; ; decidua; ; tibial arteries; ; mucosa of urinary bladder; ; ascending aorta;
	Top expressed in
	iris; ; left lung lobe; ; efferent ductule; ; stroma of bone marrow; ; ciliary body; ; gastrula; ; ascending aorta; ; aortic valve; ; vas deferens; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; zinc ion binding; metal ion binding; peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity;
Cellular component	extracellular region; basement membrane; cytoplasmic vesicle; extracellular matrix; collagen-containing extracellular matrix;
Biological process	ovulation from ovarian follicle; heart trabecula formation; kidney development; proteolysis; integrin-mediated signaling pathway; negative regulation of cell population proliferation; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell migration;
	Sources:Amigo / QuickGO
Orthologs
	9510
	11504
	ENSG00000154734
	ENSMUSG00000022893
	Q9UHI8
	P97857
	NM_006988
	NM_009621
	NP_008919
	NP_033751
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154734 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022893 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (September 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
^ "Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154734 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022893 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10438512-5] Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (September 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.

[entrez-6] "Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1".

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