ADARB1

ADARB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZY7, 5ED1, 5ED2, 5HP3, 5HP2
Identifiers
Aliases	ADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1, adenosine deaminase RNA specific B1, NEDHYMS
External IDs	OMIM: 601218; MGI: 891999; HomoloGene: 8280; GeneCards: ADARB1; OMA:ADARB1 - orthologs
EC number	3.5.4.37
Gene location (Human)
Chr.	Chromosome 21 (human)
End	45,226,560 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,254,104 bp
RNA expression pattern
	Top expressed in
	tibial arteries; ; gastric mucosa; ; right coronary artery; ; cerebellar vermis; ; saphenous vein; ; lateral nuclear group of thalamus; ; Descending thoracic aorta; ; ascending aorta; ; Achilles tendon; ; left coronary artery;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; inferior colliculi; ; cerebellar cortex; ; medulla oblongata; ; nucleus of stria terminalis; ; dentate gyrus of hippocampal formation granule cell; ; pontine nuclei; ; visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; adenosine deaminase activity; protein binding; RNA binding; double-stranded RNA binding; mRNA binding; hydrolase activity; double-stranded RNA adenosine deaminase activity; tRNA-specific adenosine deaminase activity;
Cellular component	nucleoplasm; nucleolus; nucleus; cytosol; cytoplasm;
Biological process	RNA processing; immune system process; mRNA processing; base conversion or substitution editing; regulation of cell cycle; negative regulation of cell migration; defense response to virus; negative regulation of protein kinase activity by regulation of protein phosphorylation; positive regulation of viral genome replication; innate immune response; adenosine to inosine editing; negative regulation of cell population proliferation; neuromuscular synaptic transmission; facial nerve morphogenesis; hypoglossal nerve morphogenesis; spinal cord ventral commissure morphogenesis; multicellular organism growth; neuromuscular process controlling posture; innervation; muscle tissue morphogenesis; motor behavior; motor neuron apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	104
	110532
	ENSG00000197381
	ENSMUSG00000020262
	P78563
	Q91ZS8
NM_001033049; NM_001112; NM_001160230; NM_015833; NM_015834;
	NM_001346687; NM_001346688
	NM_001024837; NM_001024838; NM_001024839; NM_001024840; NM_130895
NP_001103; NP_001153702; NP_001333616; NP_001333617; NP_056648;
	NP_056649
	NP_001020008; NP_570965; NP_001020009
	Wikidata
View/Edit Human	View/Edit Mouse

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.^[5]^[6]^[7] The enzyme is a member of ADAR family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197381 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.
^ Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743. PMID 14759252.
^ "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197381 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020262 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9143496-5] Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.

[pmid14759252-6] Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743. PMID 14759252.

[entrez-7] "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".

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