ADCYAP1R1

ADCYAP1R1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JOD
Identifiers
Aliases	ADCYAP1R1, PAC1, PAC1R, PACAPR, PACAPRI, ADCYAP receptor type I
External IDs	OMIM: 102981; MGI: 108449; HomoloGene: 870; GeneCards: ADCYAP1R1; OMA:ADCYAP1R1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	31,111,479 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	55,478,436 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; nucleus accumbens; ; caudate nucleus; ; amygdala; ; entorhinal cortex; ; right frontal lobe; ; internal globus pallidus; ; cingulate gyrus; ; anterior cingulate cortex; ; right hemisphere of cerebellum;
	Top expressed in
	paraventricular nucleus of hypothalamus; ; dentate gyrus of hippocampal formation granule cell; ; arcuate nucleus; ; lateral septal nucleus; ; Rostral migratory stream; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; substantia nigra; ; lateral hypothalamus; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; adenylate cyclase binding; neuropeptide binding; vasoactive intestinal polypeptide receptor activity; signal transducer activity; protein binding; transmembrane signaling receptor activity; signaling receptor activity; G protein-coupled peptide receptor activity; peptide hormone binding;
Cellular component	cytoplasm; integral component of membrane; endosome; rough endoplasmic reticulum; membrane; bicellular tight junction; receptor complex; plasma membrane; integral component of plasma membrane; cell surface; caveola; neuron projection; intracellular membrane-bounded organelle;
Biological process	cell differentiation; multicellular organismal response to stress; response to estradiol; positive regulation of calcium ion transport into cytosol; positive regulation of inositol phosphate biosynthetic process; negative regulation of cell death; activation of phospholipase C activity; multicellular organism development; cell surface receptor signaling pathway; development of primary female sexual characteristics; spermatogenesis; response to ethanol; cAMP-mediated signaling; signal transduction; positive regulation of small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	117
	11517
	ENSG00000078549
	ENSMUSG00000029778
	P41586
	P70205
	NM_001118; NM_001199635; NM_001199636; NM_001199637
	NM_001025372; NM_007407
	NP_001109; NP_001186564; NP_001186565; NP_001186566
	NP_001020543; NP_031433
	Wikidata
View/Edit Human	View/Edit Mouse

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC₁, is a protein that in humans is encoded by the ADCYAP1R1 gene.^[5] This receptor binds pituitary adenylate cyclase activating peptide.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078549 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
^ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078549 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029778 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid7902709-6] Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.

[pmid10835102-7] Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102.

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