ADGRL4

ADGRL4
Identifiers
Aliases	ADGRL4, ETL, KPG_003, ELTD1, adhesion G protein-coupled receptor L4
External IDs	OMIM: 616419; MGI: 2655562; HomoloGene: 11170; GeneCards: ADGRL4; OMA:ADGRL4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	79,282,124 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	151,250,723 bp
RNA expression pattern
	Top expressed in
	pericardium; ; visceral pleura; ; parietal pleura; ; subcutaneous adipose tissue; ; Achilles tendon; ; smooth muscle tissue; ; lower lobe of lung; ; gallbladder; ; vena cava; ; mammary gland;
	Top expressed in
	right lung; ; zygote; ; interventricular septum; ; right lung lobe; ; myocardium of ventricle; ; soleus muscle; ; brown adipose tissue; ; right ventricle; ; endothelial cell of lymphatic vessel; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; protein dimerization activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; cytoplasmic vesicle; membrane; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	64123
	170757
	ENSG00000162618
	ENSMUSG00000039167
	Q9HBW9
	Q923X1
	NM_022159
	NM_133222
	NP_071442
	NP_573485
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G protein-coupled receptor L4 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ADGRL4 gene.^[5]^[6] ADGRL4 appears to have a role in angiogenesis,^[7] both physiological and pathological in cancer.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039167 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nechiporuk T, Urness LD, Keating MT (February 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". The Journal of Biological Chemistry. 276 (6): 4150–7. doi:10.1074/jbc.M004814200. PMID 11050079.
^ "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".
^ Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, et al. (August 2013). "A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637.
^ Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy. 8: 3767–74. doi:10.2147/OTT.S93843. PMC 4689259. PMID 26719704.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039167 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050079-5] Nechiporuk T, Urness LD, Keating MT (February 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". The Journal of Biological Chemistry. 276 (6): 4150–7. doi:10.1074/jbc.M004814200. PMID 11050079.

[entrez-6] "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".

[pmid23871637-7] Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, et al. (August 2013). "A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637.

[8] Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy. 8: 3767–74. doi:10.2147/OTT.S93843. PMC 4689259. PMID 26719704.

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