ADRM1

ADRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KQZ, 2KR0, 2L5V, 2MKZ, 4UEL, 4UEM, 4WLQ, 4WLR, 5IRS
Identifiers
Aliases	ADRM1, ARM-1, ARM1, GP110, adhesion regulating molecule 1, PSMD16, ADRM1 26S proteasome ubiquitin receptor
External IDs	OMIM: 610650; MGI: 1929289; HomoloGene: 10513; GeneCards: ADRM1; OMA:ADRM1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	62,308,862 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	179,818,079 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right testis; ; left testis; ; muscle of thigh; ; apex of heart; ; right hemisphere of cerebellum; ; right adrenal gland; ; skin of leg; ; right adrenal cortex; ; left adrenal gland;
	Top expressed in
	muscle of thigh; ; proximal tubule; ; lip; ; muscle tissue; ; neural tube; ; yolk sac; ; skeletal muscle tissue; ; adrenal gland; ; right kidney; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endopeptidase activator activity; protease binding; proteasome binding; protein binding; ubiquitin binding;
Cellular component	proteasome complex; plasma membrane; integral component of plasma membrane; membrane; nucleus; nucleoplasm; cytoplasm; cytosol; proteasome regulatory particle, lid subcomplex;
Biological process	transcription elongation from RNA polymerase II promoter; proteasome assembly; positive regulation of endopeptidase activity; ubiquitin-dependent protein catabolic process; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	11047
	56436
	ENSG00000130706
	ENSMUSG00000039041
	Q16186
	Q9JKV1
	NM_001281437; NM_001281438; NM_007002; NM_175573
	NM_019822
	NP_001268366; NP_001268367; NP_008933; NP_783163
	NP_062796
	Wikidata
View/Edit Human	View/Edit Mouse

Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene.^[5]^[6] Recent evidences on proteasome complex structure confirmed that the protein encoded by gene ADRM1, also known in yeast as 26S Proteasome regulatory subunit Rpn13 (systematic nomenclature for proteasome subunits), is a subunit of 19S proteasome complex.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130706 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039041 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shimada S, Ogawa M, Takahashi M, Schlom J, Greiner JW (Jul 1994). "Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon". Cancer Research. 54 (14): 3831–6. PMID 8033103.
^ "Entrez Gene: ADRM1 adhesion regulating molecule 1".
^ Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W (Jan 2012). "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach". Proceedings of the National Academy of Sciences of the United States of America. 109 (5): 1380–7. doi:10.1073/pnas.1120559109. PMC 3277140. PMID 22307589.
^ Rosenzweig R, Bronner V, Zhang D, Fushman D, Glickman MH (Apr 2012). "Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome". The Journal of Biological Chemistry. 287 (18): 14659–71. doi:10.1074/jbc.M111.316323. PMC 3340268. PMID 22318722.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130706 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039041 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8033103-5] Shimada S, Ogawa M, Takahashi M, Schlom J, Greiner JW (Jul 1994). "Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon". Cancer Research. 54 (14): 3831–6. PMID 8033103.

[entrez-6] "Entrez Gene: ADRM1 adhesion regulating molecule 1".

[ReferenceA-7] Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W (Jan 2012). "Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach". Proceedings of the National Academy of Sciences of the United States of America. 109 (5): 1380–7. doi:10.1073/pnas.1120559109. PMC 3277140. PMID 22307589.

[8] Rosenzweig R, Bronner V, Zhang D, Fushman D, Glickman MH (Apr 2012). "Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome". The Journal of Biological Chemistry. 287 (18): 14659–71. doi:10.1074/jbc.M111.316323. PMC 3340268. PMID 22318722.

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